Comfort Inn Manhattan is located approximately five miles from Port Adelaide, six miles from Adelaide Zoo, and nine miles from Adelaide Airport. This location is also six miles from the Opal and Gem Mine and Rundle Mall, 22 miles from Glenelg, and 36 miles from Hahndorf.

Hotel amenities include the swimming pool and continental breakfast (fee applies). The hotel also offers room service, babysitting, laundry facilities, and free parking.

All rooms feature cable TV, dataports, hairdryers, coffeemakers, refrigerators, irons, and air-conditioning. Microwaves are available at the front desk (fee applies). Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.