Hilton Ramses is a high-rise hotel set on the Nile's east bank, next to a shopping and cinema complex, and approximately 15 miles from Cairo International Airport. This location is also next door to the Egyptian Museum, half a mile from the Opera House and Cairo Tower, five miles from the Citadel, and eight miles from the Pyramids and the Sphinx.

Hotel amenities include the outdoor swimming, sun deck and poolside food and drinks, hair and beauty salon, gymnasium, and Windows on the World, a restaurant on the 36th floor with belly dancers and views of Cairo reaching as far as the Pyramids. Terrace Cafe is an informal, 24-hour buffet restaurant overlooking the River Nile. Citadel Grill is a semi-formal restaurant with traditional Mediterranean specialties. Authentic Chinese dishes are available at Regent Chinese Restaurant and Oriental cuisince is available at Falafel Restaurant. Maharaja (Indian restaurant), Sherlock Holmes Bar & Pub, and Garden Court (coffees, cakes, and light meals) are also on site. Room service is available 24 hours a day. The hotel also offers a business center, meeting rooms, laundry facilities, and 24-hour front desk service.

All rooms feature air-conditioning, cable TV, minibars, safes, voicemail, hairdryers, bathroom telephones, bathrobes, and balconies with Nile or city views. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.