Holiday Inn Express Guanajuato is located three miles from downtown and approximately 18 miles from Guanajuato International Airport and Fipasi Industrial Park. Guanajuato is registered on the World Heritage list of UNESCO. This location is also four miles from Union Garden and the Hidalgo Market, five miles from the Diego Rivera Museum and Pipila Monument, and 22 miles from San Miguel de Allende.

The property's amenities include the indoor swimming pool, exercise room, and complimentary continental breakfast. The hotel also offers wireless Internet access, concierge assistance, babysitting, currency exchange, a business center, laundry facilities, and free parking.

All rooms feature free high-speed Internet access, cable TV, in-room movies, coffeemakers, individual climate control, voicemail, irons and ironing boards, and hairdryers. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.