With views of the Caribbean Sea, Melia Santo Domingo is approximately two miles from the Colonial Quarter and 35 minutes from Santo Domingo Las Americas International Airport. The location is near the commercial, financial, and entertainment districts, and five minutes from the city center and six blocks from the ocean.

Hotel amenities include the casino, disco, two tennis courts, outdoor freshwater pool, gift shop, spa services, business center, Cafe Casabe (24-hour restaurant), and La Canasta (island-style restaurant with Creole cuisine). The hotel also offers room service, valet laundry service, babysitting, computer rentals, and parking.

All rooms feature private marble baths, hairdryers, individual climate control, coffeemakers, voicemail, direct-dial telephones, dataports, minibars, safes, and satellite TV with pay-per-view movies and video games. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.