Sheraton Cairo Hotel is located on the west bank of the River Nile, within walking distance of the Cairo Opera House. The hotel is also within walking distance of the Mohamed Mahmoud Khalil Museum, one mile from the Egyptian Museum, and eight miles from the pyramids of Giza and the Sphinx.

Hotel amenities include Oasis Bar, La Mamma (Italian), Aladin (Lebanese), Arrous El Nil (24-hour dining), Sapporo Teppen Yaki (tapas), Tea Garden (24-hour buffet), El Mawardy, Madura (Indonesian), Casablanca Restaurant (Moroccan), and Cocktails. The hotel also offers 24-hour concierge service, 24-hour front desk, casino, fitness facility, laundry/valet service, massage treatments, outdoor children's pool, outdoor pool, pay parking facilities, steam bath, tour/excursion service, barber/beauty salon, jewelry shop, and shopping arcade.

All rooms have air-conditioning, balconies, deluxe bath amenities, free in-room movies, hairdryers, satellite TV, turndown service, and video checkout. Rates are based on double occupancy. Charges for extra adults may apply and will be due directly to the hotel.